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ASEA Study Shows Signaling Pathways in Genes After Consuming Redox Supplement
October 31, 2017Posted by on
ASEA announces results of double-blind placebo based study on its Redox cell signaling supplement.
This initial study shows ASEA Redox signaling supplement to signal human genes, which have “shut off” due to stress, toxins, age, etc., and turn them back on.
ASEA partnered with Taueret Laboratories, a leading genetic research laboratory, to conduct an observational study to understand how ASEA REDOX affects the activation of human genes. The eight-week human study was reviewed and approved by Quorum Review Independent Review Board, ensuring the ethical integrity, safety, and control of the research study. The study was a randomized double-blind placebo controlled study.
60 participants were randomly placed into three groups, 25 in an active group (ASEA REDOX), 25 in a placebo group (saline placebo), and 10 in a control group (did not drink either ASEA REDOX or placebo). The placebo was derived from the same saline solution used to create the actual ASEA REDOX for this study, but did not contain ASEA’s patented redox molecules.
Of the 60 participants, 41% were male and 59% were female, with the mean age 35. Each participant, except for the control group, drank 4 ounces of ASEA REDOX or placebo twice daily.
Participants had blood drawn at the beginning of the study and again at week eight of the study. Serum RNA was extracted using a PreAnalytix PAXgene Blood RNA Kit. Gene expression levels were then tested using Affymetrix PrimeView Array and differential expression within and between groups analyzed.
Results of the eight-week study showed a 20 – 31% difference in gene expression abundance in five genes that are involved in pathway signaling, including regulatory network pathways. Long-term consumption of ASEA REDOX resulted in stable expression changes at the eight-week time point (figure 1). These genes are key in the health of the individual and play a vital role in five human health areas and dozens of pathways.
Pathway signaling genes are unique as they have the potential to influence a multitude of biological responses. Analysis of the five genes was provided through two pathway analysis programs, PANTHER (Protein ANalysis THrough Evolutionary Relationships) and WikiPathways. An example of a gene product that was expressed in this study that interacts with multiple important pathways is the EGR1 gene.
In order to better understand how the genes reacted post-study, the ASEA REDOX group that saw the 20 – 31% change provided blood samples eight weeks post-study. The results demonstrated that all the changes seen while on the product had reverted back to their pre-study levels.
• The initial study data suggests that five genes expressed a change in transcript abundance.
• The ASEA REDOX group saw gene activation results in regulatory pathway related genes that signal dozens of important biological functions.
• The ASEA REDOX and the placebo (saline) behaved differently.
• There were no harmful changes in the gene expression trends of the participants consuming either beverage during the course of the study. This is representative of long-term safety.
• Daily consumption of ASEA REDOX over eight weeks appears to result in stable expression changes.
• Changes in gene expression eight weeks post study in the ASEA REDOX group were no longer observed. This suggests continued use of ASEA REDOX is necessary to sustain the observed gene expression results.
• Effects of consuming ASEA REDOX are systemic.
• Effects are non-specific to race, sex or age, and were observed in all populations tested.